Chapter 18
Self-Quiz
Unit 3: Genetics
Harnessing the Human Genome
Review
Genomics is the study of the entire
of an organism and how it evolves over time.
The human genome has been completely sequenced in
in a competitive effort between the Human Genome Project
(HGP)
and the private
Celera.
The
data
is published in the public
GenBank
database.
The human genome is now estimated to be
to
genes, and the sequencing of genes has enabled us to compare human
with those of other species, providing further insight into
relationships.
Genetic
using DNA
can now identify large numbers of Single
Nucleotide
(SNPs)
to assess an individual's risks for an entire set of diseases.
Chapter 20
Self-Quiz
Unit 4: Evolution
Evolution of Populations
Review
Evolution occurs at the population level when the
and
frequencies of the population
change
over time.
In the absence of evolution, allele frequencies reach the
equilibrium under five idealized conditions:
There is no change in allele frequencies due to
.
There is no
gene
due to migration of individuals in or out of the population.
The population contains a
number of individuals.
Members of the population mate
.
Natural
does not occur.
Under Hardy-Weinberg
equilibrium,
the distribution of 2 alleles
p
and
q
in a population can be
modeled
by these
equations
:
The
frequencies are described by
p
+
q
= 1, where
p
is the dominant allele frequency and
q
is the recessive allele frequency.
The
frequencies are described by
p
2
+ 2
pq
+
q
2
= 1.
Mutation
is the ultimate source of genetic variation. An example of a
mutation is the resistance to pesticides in both
Culex pipiens
and
Anopheles gambiae
mosquitoes due to a change in one amino acid of an enzyme.
Gene
flow
and
can affect genetic diversity of populations.
Genetic drift due to
events can lead to
fixation
of alleles. Small populations that approach fixation for many alleles face a
genetic
where lack of genetic
reduces their ability to
to changing environments. An example is the
,
Felis concolor
.
Nonrandom
mating such as
sexual
may affect the reproduction success of alleles.
Natural selection shapes the evolution of populations in three ways.
selection favors one
extreme
form of the population.
selection favors both
extremes
of the population.
selection favors
individuals
near the population
mean.
Heterozygous advantage occurs when
leave more offspring than homozygotes. An example is the
cell anemia
allele
which confers some resistance to
in heterozygotes.
The ability of populations to evolve rapidly has serious implications for humans. Examples include pesticide
in insects, antibiotic
resistance
in bacteria, and the elusive quest for an effective treatment against
infection.
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