DNA - The Master Molecule (computer simulation) (continued)

  1. INTRODUCTION TO MUTATIONS
    Mutation Simulation

    A mutation in this DNA sequence
    CTG ACA TAC GGC GGT yields this new sequence:
    CTG ACA ACT ACG GCG GT

    1. What type of mutation occurred?
      1. Point
      2. Addition
      3. Deletion

    2. How did the mutation affect the amino acid sequence?
      1. Missense - the substitution of one amino acid for another
      2. A large alteration of the amino acid sequence
      3. Nonsense - premature termination of the amino acid sequence
      4. No change

  2. PROMOTERS AND PROTEIN FOLD STRUCTURE

    The amino acids of a protein are linked together by a process called ________________________ synthesis.
    The acid group of one amino acid bonds to the ________________ group of the next, forming a ____________________ bond
    and releasing a molecule of ________________.

    Wool is a protein with ______________________________ secondary structure, giving it flexibility and elasticity.

    Silk is a protein fiber with _______________________________ secondary structure,
    containing at least four amino acids linked together by ________________ bonds.

    A ____________________ allows an amino acid chain to reverse direction by folding back on itself, producing a hairpin turn.

    Some amino acid sequences in a protein do not have a structure and take on a _________________ form.

  3. MUTATIONS AND PROTEIN FOLD SIMULATION

    Choose one of these genes:

    • Short Gene- Somatostatin
    • Long Gene - Glucagon
    • Custom Gene - Enter up to 105 bases

    Perform each of these mutations: (within the promoter TATAATG, or 25-30 bases after the promoter)

    • Point
    • Addition
    • Deletion

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